The Global Drug sales of Neulasta stood at USD 1,126 Millions in 2022
The indicator recorded a historical decline (CAGR) of30% between 2019 to 2022 and is expected to decline by ...
GlobalData projects the indicator to decline at a CAGR of...
Pegfilgrastim (Neulasta) is a covalent conjugate of recombinant human granulocyte colony stimulating factor G-CSF with polyethylene glycol (PEG) molecule. It is formulated as pegylated injectable solution for subcutaneous route of administration.
Mechanism of Action
Pegfilgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Pegfilgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Pegfilgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, pegfilgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase. Neulasta is a white blood cell booster to help support your natural defenses and help reduce the risk of infection in patients with some tumors receiving strong chemotherapy. Granulocyte colony-stimulating factor (G-CSF) receptor (GcR) mediates growth and differentiation signals in the granulocyte/monocyte lineage of hematopoietic cells.
Neulasta Overview
Neulasta is marketed for the treatment of several indications in Hematological Disorders, and Toxicology therapy areas.
Neulasta is indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia. Neulasta is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in adult patients treated with cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes). Neulasta is indicated to increase survival in patients acutely exposed to myelosuppressive doses of radiation.
Neulasta was first approved in 2002 and is sold globally including the US, the UK, France, Germany, and Japan by several pharma giants including Kyowa Kirin Co Ltd, and Amgen Inc. Neulasta drug sales recorded a low-double digit Year on Year decline in 2022. Neulasta drug sales include the historical sales that are derived from company financial reports, and consensus forecasts are calculated based on company-specific broker reports as well as GlobalData’s proprietary methodology.
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